Treatment of Burn Injuries: HBS Collagen Products Can be More Effective in Advanced Wound Care

During the study period, the hospitals received approximately one patient with firecracker-related injury per 1,00,000 population of the city.

1. An estimated 180 000 deaths every year are caused by burns - the vast majority occur in low- and middle-income count

2. Non-fatal burn injuries are a leading cause of morbidity.

3. In India, over 1 000 000 people are moderately or severely burnt every year.

Nearly 300 children and adolescents die from fire or burn injuries each year, and over 100,000 are admitted to a hospital or treated in an emergency department.

In burn injuries damage is caused to the skin superficially and deeper, into underlying structures, depending on the length of time or degree to which a person is exposed to fire. The cause, size and severity of the burn will greatly determine the survivor's pain levels, treatment and recovery. Initial care of patients with severe burn injuries presents challenges in airway management, vascular access and hemodynamic and pulmonary support.

In regard to skin healing after a burn injury, early excision of dead/necrotic tissue with temporary or permanent coverage of the open areas decreases the chance of wound colonization and systemic sepsis. It has become the standard of care . The aim of treatment in burn injury is to control infection and promote wound and burn healing with good aesthetic results.

Recently, collagen-based dressings for acute burn wound management have been extensively used in India and worldwide. Dr. Sunil M. Kewsani Plastic Surgeon at National Burn Center in Mumbai India says, "We found SkinTemp very useful when applied immediately after injury when brought into the hospital. SkinTemp is life saving for burn cases."

Wound healing and regeneration involve cell proliferation, cell migration, cell differentiation, and interaction between the different components .Collagen-based products provide a natural hemostat that regulates the wound and stops initial bleeding. The sheet and particle forms of collagen will bind with exudate and white blood cells when helping to debride mild necrotic tissue by encouraging autolytic debridement. For drier wounds with slough, collagen gel can donate moisture, also assisting with the removal of dead tissue. As the wound process continues, collagen encourages new granulation tissue and capillary formation to fill in the wound surface through re-epithelialization. A strong, smooth scar is achieved faster with better structural integrity due to organized collagen bonds.

The Chief of the Burn Unit in Choithram Hospital and Research Center, Dr. ShabhaChamania says, "SkinTemp is very useful for facial burns especially around the ears and residual wounds after grafting. It heals the deep partial-thickness burns by helping with epithelialization."

All aspects of burn injury (e.g., dressing changes, excision and grafting procedures, physical therapy, and line insertion) are associated with pain. There is ongoing background pain as well as procedure-related pain. This pain is exacerbated by anxiety if the pain is poorly controlled .Collagen-based dressings are soft, pliable, and naturally occurring. They are easy to remove with gentle cleansing of the wound and burns versus the need for significant scrubbing or irrigation to limit non-biologic residue that could risk damage to newly formed granulation tissue and capillary buds.

Frequently, collagen-based dressings are absorbed into the wound bed with little need for trauma during dressing changes and easily reapplied daily or less often depending on wound drainage and dislodgement needs through regular wear. With easier and less frequent dressing changes, less medication and nursing care are required. Patients are likely more capable of participating in other aspects of their recovery like mobility, self-care and therapy services leading to a faster recovery overall.

Human Biosciencesproducts contain native non-hydrolyzed Type -1 bovine collagen in its purest form with three modes of delivery for Kollagen technology:

Collatek Gel would be most appropriate for dry wound beds requiring additional moisture.

SkinTemp II Sheets would be suitable for coverage of flat shallow surfaces.

Medifil® II Particles

Dr. Rohan Jain, President of Human BioSciences confirms the mission stating, "We believe that people should not have to choose between their lives, their livelihoods, and their limbs. To that end, we intend to focus on delivering the world's most cutting edge wound care technology globally."

Human BioSciences (HBS) Inc. is a specialty biotechnology company focused on developing, manufacturing, and selling advanced wound care products utilizing the proprietary Kollagen technology, popularly known as SkinTemp II Dressing Sheets, Medifil II Particles and Collatek Gel worldwide. These products have are proven to speed up the healing of chronic or slow-healing wounds.

Since 1990, the company's innovative collagen-based wound care products have helped heal millions of serious wounds worldwide in thousands of hospitals, clinics, Army training Centers & War zones.

The main headquarters and primary production facility is located in Gaithersburg, Maryland, with another factory Human BioSciences India Pvt. Ltd., located in Ahmedabad, India, with FDA-compliance and ISO 13485 certified.

Current products Medifil II and Skin Temp II are considered more effective than traditional wound dressings as it helps to stop the bleeding immediately, providing faster wound healing and a better aesthetic appearance with minimal scarring. Appropriate for use and management of burns, scrapes, sores, ulcers, acute and chronic wounds, superficial, partial and full-thickness wounds, infected and non-infected wounds, and minimal to heavily exudating wounds. Medifil II is an absorbable collagen-based granule and Skin Temp II is a solid sheet. Both formulations of HBS products are known for easy application and compatibility with various topical agents and cover dressings.

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