Los Angeles: In a shocking twist in medical drama 'Grey's Anatomy', the beloved original character Dr Derek Shepherd aka McDreamy was killed off in a car accident. Played by Patrick Dempsey, Derek, a brain surgeon, was married to Meredith Grey in the ABC drama.

The death was met with shock by its fans on Twitter. The development is said to be surprising as Dempsey, 49, had signed a two-year contract extension last year that would have kept him on Grey's through a 12th season, reported People magazine.