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Decoded: Researchers find out how our body fights stress

The study provides more support for the hypothesis that these endogenous cannabinoid molecules are a body’s natural coping response to stress.  Stress exposure heightens risk for the development or worsening of psychiatric disorders from generalised anxiety and major depression to post-traumatic stress disorder (PTSD)

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Image for representational purpose only. Photo Courtesy: istock

Image for representational purpose only. Photo Courtesy: istock

Ever wondered how our body fights stress? Researchers, including one of Indian-origin, have found that during stress, our brain releases its own cannabinoid molecules to calm us down, activating the same brain receptors as THC derived from cannabis plants. But the brain activity patterns and neural circuits that are regulated by these brain-derived cannabinoid molecules were not well known.

A team from the Northwestern University in the US, in a mice study, discovered that a key emotional brain centre, the amygdala, releases endogenous (the body’s own) cannabinoid molecules under stress, and these molecules dampen the incoming stress alarm from the hippocampus -- a memory and emotion centre in the brain. 

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