INST researchers develop new therapy for Alzheimer’s Disease

Researchers at the Institute of Nano Science and Technology INST Mohali have identified a new pathway involving nanoparticles to treat Alzheimerrsquos Disease AD said the Ministry of Science amp Technology on TuesdayConventional Alzheimerrsquos therapies often target only a single pathological feature such as amyloid aggregation or oxidative stress yielding limited clinical benefitHowever the new therapy involves nanoparticles that integrate polyphenol with antioxidant properties found in green tea a neurotransmitter and an amino acidIt has the potential to treat Alzheimerrsquos Disease by changing the path of the progression of the disease slowing it improving memory and supporting thinking skills said the researchers in the paper published in the journal SmallThe therapy works by integrating epigallocatechin3gallate EGCG an antioxidant found in green tea dopamine a neurotransmitter important for mood and tryptophan an amino acid involved in many cellular functions into a nanoparticle called EGCGdopaminetryptophan nanoparticles EDTNPsThis enables it to simultaneously target amyloid aggregation oxidative stress inflammation and neuronal degeneration four key pathological hallmarks of AlzheimerrsquosldquoIncorporation of BrainDerived Neurotrophic Factor BDNF a protein crucial for the survival growth and function of neurons onto EDTNPs BEDTNPs creates a dualaction nanoplatform that not only clears neurotoxic Amyloid Beta aggregates protein clumps that disrupt neural function and drive Alzheimerrsquos disease pathology but also enhances neuronal regenerationrdquo said the team led by Dr Jiban Jyoti Panda from INST an autonomous institute of the Department of Science and Technology DSTldquoThis is a rare approach in Alzheimerrsquos therapeutics which uniquely combines antioxidant antiamyloid and neurotrophic actions for the therapyrdquo they addedThe research conducted with support from Dr Ashok Kumar Datusalia NIPER Raebareli and Dr Nisha Singh Gujarat Biotechnology University involves the synthesis of EDTNPs using biocompatible assembly techniques like pressureassisted hydrothermal and electrostaticbased coincubation methods to combine antioxidant neurotransmitter and amino acid componentsThese nanoparticles were then functionalised with BDNF producing BEDTNPs with enhanced neuroprotective potentialIn lab experiments and mouse models these nanoparticles disassembled toxic plaques reduced inflammation restored balance inside brain cells and even improved memory and learning Computer simulations further confirmed that the nanoparticles latch onto harmful Amyloid beta fibrils and pull them apart at the molecular levelldquoThe research could help people with Alzheimerrsquos disease by offering a treatment that works on multiple levels The nanoparticles not only remove harmful protein plaques but also reduce brain stress inflammation and help nerve cells grow through BDNFrdquo said the researchersThis story has been sourced from a third party syndicated feed agencies Midday accepts no responsibility or liability for its dependability trustworthiness reliability and data of the text Midday managementmiddaycom reserves the sole right to alter delete or remove without notice the content in its absolute discretion for any reason whatsoever