Huma Qureshi made her acting debut with the film 'Gangs of Wasseypur' directed by Anurag Kashyap in 2012. With the cult classic status of the film, the debut was nothing short of a dream for Qureshi. While the film changed her world, she also could not help but feel lost  in 2012. 

'Gangs Of Wasseypur' also starred Nawazuddin Siddiqui and Manoj Bajpayee. In an interview with journalist Barkha Dutt, Huma spoke about her debut film and the challenges that followed.