Filmmaker Sam Raimi wanted to make a fourth Spider-Man movie, following his Tobey Maguire-fronted trilogy, but the film did not receive the go-ahead after the critical mauling of the third film. Raimi directed the original Spider-Man trilogy and post the bashing the third installment received, he and the studio, Sony Pictures, decided not to make any more movies in the series.

The fourth movie, according to storyboard artiste Jeffrey Henderson, would have featured classic villains The Vulture and Mysterio against Maguire's web-slinger, reported IndieWire. Both the villains were introduced on the big screen within the Marvel Cinematic Universe (MCU).