Speculations are rife that the latest season of Grey's Anatomy would be the last one. Rumours of the Ellen Pompeo-fronted series culminating with its ongoing 17th season first gathered steam after the actor apparently alluded to the same. The claims found credence in the fact that several former cast members, whose characters had been killed in previous seasons, have been making cameo appearances.

Among the returning cast-members were Patrick Dempsey, and more recently, TR Knight, both of who are seen interacting with Pompeo's hallucinating Meredith Grey, as she walks the thin line between life and death while battling COVID-19.