Excessive levels of vit D can be as unhealthy as too little

Research shows higher mortality in people with too high levels of vitamin D in their bloodstream

While it is known that vitamin D deficiency is not good for health, a new study has now suggested that too high a level of the essential vitamin is not good either.

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The new research from the University of Copenhagen is based on blood samples from 247,574 Copenhageners.

Vitamin D is instrumental in helping calcium reach our bones, thus lessening the risk from falls and the risk of broken hips.

Research suggests that vitamin D is also beneficial in combating cardiac disease, depression and certain types of cancers. The results from a study conducted by the Faculty of Health and Medical Sciences now support the benefits of vitamin D in terms of mortality risk.

However, the research results also show higher mortality in people with too high levels of vitamin D in their bloodstream:

“We have had access to blood tests from a quarter of a million Copenhageners. We found higher mortality in people with a low level of vitamin D in their blood, but to our surprise, we also found it in people with a high level of vitamin D. We can draw a graph showing that perhaps it is harmful with too little and too much vitamin D,” explained Darshana Durup, PhD student.

If the blood contains less than 10 nanomol (nmol) of vitamin per litre of serum, mortality is 2.31 times higher. However, if the blood contains more than 140 nmol of vitamin per litre of serum, mortality is higher by a factor of 1.42. Both values are compared to 50 nmol of vitamin per litre of serum, where the scientists see the lowest mortality rate.

Darshana Durup emphasised that while scientists do not know the cause of the higher mortality, she believes that the new results can be used to question the wisdom of those people who claim that you can never get too much vitamin D.

“It is important to conduct further studies in order to understand the relationship. A lot of research has been conducted on the risk of vitamin D deficiency. However, there is no scientific evidence for a ‘more is better’ argument for vitamin D, and our study does not support the argument either. We hope that our study will inspire others to study the cause of higher mortality with a high level of vitamin D,” said Durup.

“We have moved into a controversial area that stirs up strong feelings just like debates on global warming and research on nutrition. But our results are based on a quarter of a million blood tests and provide an interesting starting point for further research.”

The study is the largest of its kind – and it was only possible to conduct it because of Denmark’s civil registration system, which is unique in the Nordic countries. The 247,574 blood samples come from the Copenhagen General Practitioners Laboratory.

“Our data material covers a wide age range. The people who participated had approached their own general practitioners for a variety of reasons and had had the vitamin D level in their bloodstream measured in that context. This means that while the study can show a possible association between mortality and a high level of vitamin D, we cannot as yet explain the higher risk,” Durup added.

The study has been published in the Journal of Clinical Endocrinology and Metabolism.

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