shot-button
Ganesh Chaturthi Ganesh Chaturthi
Home > Lifestyle News > Health And Fitness News > Article > High salt intake can cause cognitive disorders high blood pressure Study

High salt intake can cause cognitive disorders, high blood pressure: Study

Updated on: 31 May,2023 09:37 AM IST  |  Tokyo (Japan)
IANS |

Cognitive impairment has been linked to the consumption of excess table salt, a ubiquitous food seasoning. High salt (HS) intake can also lead to hypertension. To prevent adverse health outcomes, the World Health Organization recommends limiting salt intake to less than 5 g per day

High salt intake can cause cognitive disorders, high blood pressure: Study

Excessive salt intake is considered a risk factor for hypertension, cognitive dysfunction, and dementia. However, studies focusing on the interaction between the peripheral and central nervous system have not sufficiently investigated this association. Photo Courtesy: iStock

Dementia is described as a loss of cognitive functioning, which included thinking, remembering, and reasoning, and it is quite common in Japan. At the moment, treatment satisfaction for dementia is among the lowest, and no medication therapy to cure the condition is available. With the world's population increasingly ageing, the discovery of dementia prevention and treatment medications is crucial.


Cognitive impairment has been linked to the consumption of excess table salt, a ubiquitous food seasoning. High salt (HS) intake can also lead to hypertension. To prevent adverse health outcomes, the World Health Organization recommends limiting salt intake to less than 5 g per day. The involvement of angiotensin II (Ang II)--a hormone that plays a key role in regulating blood pressure and fluid balance--and its receptor "AT1", as well as that of the physiologically important lipid molecule prostaglandin E2 (PGE2 and its receptor "EP1" in hypertension and neurotoxicity is well-recognized. However, the involvement of these systems in HS-mediated hypertension and emotional/cognitive impairment remains elusive.


To this end, a recent study published in the British Journal of Pharmacology thoroughly evaluated the aspects of HS-mediated hypertension and emotional/cognitive impairment. The study was performed by a team of collaborating researchers from Japan, and has shown how hypertension, mediated by the crosstalk between Ang II-AT1 and PGE2-EP1 causes emotional and cognitive dysfunction.


Author Hisayoshi Kubota from Fujita Health University's Graduate School of Health Science comments, "Excessive salt intake is considered a risk factor for hypertension, cognitive dysfunction, and dementia. However, studies focusing on the interaction between the peripheral and central nervous system have not sufficiently investigated this association."

According to the published data, the addition of excessive phosphates to the protein "tau" is primarily responsible for these emotional and cognitive consequences. The findings are particularly noteworthy because tau is a key protein of Alzheimer's disease.

The team first loaded laboratory mice with an HS solution (2 per cent NaCl in drinking water) for 12 weeks and monitored their blood pressure. "The effects of HS intake on emotional/cognitive function and tau phosphorylation were also examined in two key areas of the mouse brain--the prefrontal cortex and the hippocampus," explains Prof. Mouri. Next, they also studied the involvement of the Ang II-AT1 and PGE2-EP1 systems in HS-induced hypertension and neuronal/behavioural impairment.

The results were remarkable and encouraging: The brains of the experimental mice had several biochemical alternations. At the molecular level, besides the addition of phosphates to tau, the researchers also observed a decrease in the phosphate groups linked to a key enzyme called "CaMKII"--a protein involved in brain signalling. Moreover, changes in the levels of "PSD95"--a protein that plays a vital role in the organization and function of brain synapses (connection between brain cells)--were also evident. Interestingly, the biochemical changes were reversed after the administration of the antihypertensive drug "losartan." A similar reversal was observed after knocking out the EP1 gene.

Overall, these findings suggest that angiotensin II-AT1 and prostaglandin E2-EP1 systems could be novel therapeutic targets for hypertension-induced dementia.

Also Read: World No Tobacco Day: Cancer surgeon warns against smoking, here's how to detect oral cancer early

This story has been sourced from a third party syndicated feed, agencies. Mid-day accepts no responsibility or liability for its dependability, trustworthiness, reliability and data of the text. Mid-day management/mid-day.com reserves the sole right to alter, delete or remove (without notice) the content in its absolute discretion for any reason whatsoever

"Exciting news! Mid-day is now on WhatsApp Channels Subscribe today by clicking the link and stay updated with the latest news!" Click here!

Register for FREE
to continue reading !

This is not a paywall.
However, your registration helps us understand your preferences better and enables us to provide insightful and credible journalism for all our readers.

Mid-Day Web Stories

Mid-Day Web Stories

This website uses cookie or similar technologies, to enhance your browsing experience and provide personalised recommendations. By continuing to use our website, you agree to our Privacy Policy and Cookie Policy. OK