Dementia is described as a loss of cognitive functioning, which included thinking, remembering, and reasoning, and it is quite common in Japan. At the moment, treatment satisfaction for dementia is among the lowest, and no medication therapy to cure the condition is available. With the world's population increasingly ageing, the discovery of dementia prevention and treatment medications is crucial.

Cognitive impairment has been linked to the consumption of excess table salt, a ubiquitous food seasoning. High salt (HS) intake can also lead to hypertension. To prevent adverse health outcomes, the World Health Organization recommends limiting salt intake to less than 5 g per day. The involvement of angiotensin II (Ang II)--a hormone that plays a key role in regulating blood pressure and fluid balance--and its receptor "AT1", as well as that of the physiologically important lipid molecule prostaglandin E2 (PGE2 and its receptor "EP1" in hypertension and neurotoxicity is well-recognized. However, the involvement of these systems in HS-mediated hypertension and emotional/cognitive impairment remains elusive.