The struggles for weight gain among women are real, if not heard of much. A team of scientists from the Baylor College of Medicine explored the concept and tried to find out why is it hard for ladies to gain weight. For years, experts have observed that when male and female mice eat the same high-fat diet, the males gain significantly more weight than the females. The reasons for this difference between sexes are not completely understood, but the new study proposes that part of the answer may be in the brain.