A 52-year-old gentleman, who had been suffering from severe stiffness and difficulty walking for months, has shown a remarkable improvement following treatment with intravenous immunoglobulin (IVIG) therapy. After experiencing progressive tightness in his back and legs, the patient found it increasingly difficult to walk more than 200-300 meters without the onset of intense muscle stiffness, which led to him losing his balance and needing to catch hold of nearby walls for support.

Initially, the patient’s condition raised concerns for possible spinal canal stenosis and vascular claudication, but after thorough testing, including MRI and Doppler scans, no such conditions were found. With the clear absence of clues in the investigations pertaining to common neurological and vascular issues, a clinical diagnosis of Stiff Person Syndrome (SPS) was made.