Study uncovers key genes behind Parkinson's in young Indians

A team of scientists has identified key genes that raise the risk of Parkinsons disease in young IndiansThe team led by Parkinsons Research Alliance of India PRAI and MedGenome a global genomics company in South Asia made a comprehensive analysis of rare and common genetic variations in young Indian population which can enhance the understanding of the genetic basis of Parkinsons diseaseThis also opens door for a firstever genetic screening in India for the disease in highrisk individuals and affected families said the team of scientists in the paper published in the prestigious journal Movement DisordersParkinsonrsquos is not a single gene disease It can occur due to multiple genetic mutations and multiple gene causes Knowing what patients with Indian patients will have it will have more impact in understanding and treatment of that Dr Prashanth LK a specialist in movement disorders from PRAI told IANSParkinsonrsquos disease is the second most common neurodegenerative disorder in adults in the age bracket of 60 years and aboveAccording to the Global Burden of Disease Study 2018 Parkinsons has doubled across the globe over the past two decades while India accounts for approximately 10 per cent of the global burden This translates to nearly 058 million patients living with the disease in the countryThe first of its kind study conducted in India aimed included 1000 patients through a network of 10 specialty Movement Disorder CentersNeurology clinics across IndiaDr Prashanth said that the team found high probability of nonmutation and Parkinsons mutations are quite common in Indian patientWe also found a lot of what we call it is variants of unknown significance These are all important genes which have not been reported in literature and have been found hereWe need to work on these genes further to see how these genes can be important for occurrence of parkinson disease in in in patients he saidFurther the expert noted that Indian patients carry lot of BSN gene mutations BSN gene primarily affects gait and balance for people and is normally not reported in ParkinsonsDr Prashanth also noted that currently there is single answer as to how to prevent the disease because Parkinson disease is an ageing related disorderHowever very important is good quality of life proper food timing food timings regular exercisesHe also emphasised the need for a stressfree lifeThis story has been sourced from a third party syndicated feed agencies Midday accepts no responsibility or liability for its dependability trustworthiness reliability and data of the text Midday managementmiddaycom reserves the sole right to alter delete or remove without notice the content in its absolute discretion for any reason whatsoever