Israeli strikes across Gaza killed 19 people overnight, including a woman and her six children, as US Secretary of State Antony Blinken headed to the region on Sunday to try to seal a cease-fire deal after months of contentious negotiations.

The US and fellow mediators Egypt and Qatar said they were closing in on a deal after two days of talks in Doha, with American and Israeli officials expressing cautious optimism. But Hamas has signaled resistance. The latest Israeli bombardment included a strike early Sunday on a home in the central town of Deir al-Balah that killed a woman and her six children, according to the Al-Aqsa Martyrs Hospital. An Associated Press reporter at the hospital counted the bodies.