In a setback to Pakistan's ruling PPP, senior party leader and Information Minister Sherry Rehman on Saturday resigned from the Cabinet after differences emerged with top leadership over the government's handling of media.

Rehman, a former journalist and a close aide of slain PPP chairperson and former premier Benazir Bhutto, put in her papers early this morning after differences emerged on the issue of handling the media in the context of the ongoing political crisis at a high-level meeting, media reports said.