Russia’s southern Belgorod region bordering Ukraine came under attack from Ukrainian artillery fire on Friday, authorities said, hours after at least one nighttime blast rocked a Russian city in a region next to the annexed Crimea peninsula.

The Kremlin’s forces, meanwhile, struck a clinic in Dnipro, in central Ukraine, killing one person and wounding 16 including two children, Ukrainian officials said. Also, a Russian S-300 missile hit a dam in the Karlivka district of Ukraine’s eastern Donetsk province, placing nearby settlements under threat of severe flooding.