Kei Nishikori, the 2014 US Open runner-up, withdrew from the year’s last Grand Slam tournament after being sidelined all month with an injured left knee.
Nishikori was replaced in the men’s singles draw at Flushing Meadows by James Duckworth, who lost in qualifying. 

Nishikori is a 33-year-old from Japan who had an operation on his hip in January 2022. He returned to the ATP Tour in late July at Atlanta, where he won two matches to reach the quarter-finals before losing to Taylor Fritz.